Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482564 | 0.91 | SMPD1 (0.51) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20482676 | 0.81 | SMPD1 (0.52) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20482610 | 0.80 | MAPK1 (0.52) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20482692 | 0.79 | KMT2A (0.47) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20482672 | 0.76 | REN (0.46) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL2394315 | 0.74 | SMPD1 (0.59) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL2391945 | 0.74 | SMPD1 (0.61) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20482522 | 0.73 | REN (0.44) | SMPD1ALDH1A1 | |
| SCHEMBL10730593 | 0.73 | SMPD1 (0.60) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL3239903 | 0.72 | BCHE (0.60) | SMPD1HDAC1HDAC8HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |