Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482779 | 0.92 | REN (0.47) | RENSMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL20482383 | 0.82 | REN (0.43) | RENSMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL20482607 | 0.80 | REN (0.42) | RENSIGMAR1 | |
| SCHEMBL20482522 | 0.78 | REN (0.44) | RENSMPD1ALDH1A1 | |
| SCHEMBL20482549 | 0.77 | REN (0.44) | RENALDH1A1 | |
| SCHEMBL20482253 | 0.76 | SMPD1 (0.52) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL20483534 | 0.76 | REN (0.48) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL20482558 | 0.74 | MEN1 (0.45) | RENSMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL20482717 | 0.72 | KMT2A (0.47) | RAB9AALDH1A1 | |
| SCHEMBL20482664 | 0.72 | REN (0.45) | RENSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |