Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394250 | 0.91 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL30844598 | 0.91 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL1990848 | 0.89 | SLC6A2 (0.57) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL14914125 | 0.87 | SMPD1 (0.59) | KMT2ALMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL2590133 | 0.87 | RAB9A (0.56) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL4914162 | 0.87 | MRGPRX4 (0.57) | KMT2ARAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL30141105 | 0.87 | KMT2A (0.62) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL3960907 | 0.87 | KMT2A (0.62) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL289420 | 0.85 | KMT2A (0.60) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL6287009 | 0.85 | KMT2A (0.64) | KMT2ATDP1SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |
| CN-1179960-C | Indole derivatives and their use in the treatment of osteoporosis and other uses | ʷ��˿�������ȳ�ķ�ɷݹ�˾ | 2004-12-15 | — | — | CN | disclosed |
| CN-1370159-A | Indole derivatives and their use for treatment of osteoporosis amongst other applications | SMITHKLINE BEECHAM SPA (IT) | 2002-09-18 | — | — | CN | disclosed |