Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20483174 | 0.98 | SLC6A4 (0.36) | HTR1AKDM4EMEN1KMT2ASLC6A2 | |
| SCHEMBL20482538 | 0.88 | KDM4E (0.33) | HTR1AKDM4EMEN1KMT2ASLC6A4 | |
| SCHEMBL20482446 | 0.85 | TSHR (0.38) | HTR1AKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20482240 | 0.83 | REN (0.41) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20482988 | 0.80 | HTR1A (0.40) | HTR1AKDM4EMEN1KMT2AADRA1B | |
| SCHEMBL20482226 | 0.79 | HPGD (0.40) | HTR1AKDM4EMEN1KMT2AADRA1B | |
| SCHEMBL20482792 | 0.78 | REN (0.40) | KMT2ALMNAHTT | |
| SCHEMBL20482372 | 0.78 | REN (0.40) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL20482542 | 0.77 | ITGB1 (0.41) | HTR1AKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL20482585 | 0.76 | L3MBTL1 (0.36) | HTR1AMEN1KMT2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |