Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29797543 | 0.88 | GPR119 (0.47) | GPR119NAMPT | |
| SCHEMBL23565693 | 0.88 | GPR119 (0.47) | GPR119NAMPT | |
| SCHEMBL31647332 | 0.81 | BRD4 (0.45) | NAMPTBRD4CREBBPL3MBTL1GRM2 | |
| SCHEMBL7037315 | 0.80 | NAMPT (0.48) | NAMPTBRD4CREBBPL3MBTL1GRM2 | |
| SCHEMBL5846227 | 0.79 | GPR119 (0.53) | GPR119BRD4CREBBP | |
| SCHEMBL29089801 | 0.77 | CACNA1H (0.43) | GPR119NAMPTBRD4CREBBPL3MBTL1 | |
| SCHEMBL3834548 | 0.76 | NAMPT (0.39) | NAMPTBRD4CREBBPL3MBTL1GAA | |
| SCHEMBL27086229 | 0.76 | CLK4 (0.40) | GPR119PARP1PDCD1CD274 | |
| SCHEMBL8228693 | 0.76 | ROCK2 (0.45) | NAMPTL3MBTL1 | |
| SCHEMBL17350021 | 0.76 | NAMPT (0.49) | NAMPTBRD4CREBBPL3MBTL1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |