Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16124509 | 0.77 | HDAC1 (0.46) | NAMPTL3MBTL1HDAC1KDM4AKDM4E | |
| SCHEMBL2048612 | 0.76 | GPR119 (0.46) | NAMPTL3MBTL1BRD4CREBBPPARP1 | |
| SCHEMBL15700313 | 0.73 | HDAC1 (0.44) | NAMPTL3MBTL1HDAC1KDM4AGAA | |
| SCHEMBL13055397 | 0.73 | KDM4A (0.51) | NAMPTL3MBTL1HDAC1KDM4AKDM4E | |
| SCHEMBL29089801 | 0.70 | CACNA1H (0.43) | NAMPTL3MBTL1BRD4CREBBPPARP1 | |
| SCHEMBL7037315 | 0.70 | NAMPT (0.48) | NAMPTL3MBTL1BRD4CREBBPHDAC1 | |
| SCHEMBL2959710 | 0.70 | HDAC1 (0.40) | NAMPTL3MBTL1BRD4HDAC1KDM4A | |
| SCHEMBL25217202 | 0.70 | L3MBTL1 (0.46) | NAMPTL3MBTL1BRD4CREBBPHDAC1 | |
| SCHEMBL31647332 | 0.70 | BRD4 (0.45) | NAMPTL3MBTL1BRD4CREBBPPARP1 | |
| SCHEMBL626784 | 0.70 | GAA (0.52) | NAMPTL3MBTL1HDAC1KDM4AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |