⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455831 | 0.77 | — | — | |
| SCHEMBL27781000 | 0.74 | — | — | |
| SCHEMBL18705863 | 0.73 | — | — | |
| SCHEMBL8939781 | 0.71 | CALM1 (0.41) | — | |
| SCHEMBL462426 | 0.70 | HTR2A (0.36) | — | |
| SCHEMBL3430534 | 0.69 | — | — | |
| SCHEMBL78405 | 0.67 | — | — | |
| SCHEMBL15066318 | 0.64 | ACHE (0.31) | — | |
| SCHEMBL15066317 | 0.64 | ACHE (0.31) | — | |
| SCHEMBL6180154 | 0.64 | CYP3A4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018160855-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2018-09-07 | — | — | WO | claimed |
| WO-2018160855-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2018-09-07 | — | — | WO | disclosed |
| WO-2018160824-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2018-09-07 | — | — | WO | disclosed |