Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106395 | 0.83 | CALM1 (0.39) | CALM1HTR2AALOX5BCL2BCL2L1 | |
| SCHEMBL16798254 | 0.81 | CALM1 (0.38) | CALM1ALOX5ALDH1A1 | |
| SCHEMBL8859945 | 0.80 | CALM1 (0.37) | CALM1HTR2ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7459473 | 0.78 | CALM1 (0.42) | CALM1HTR2AALOX5BCL2BCL2L1 | |
| SCHEMBL8466360 | 0.77 | CALM1 (0.55) | CALM1HTR2ABCL2BCL2L1TAAR1 | |
| SCHEMBL455831 | 0.71 | — | — | |
| SCHEMBL20487629 | 0.71 | LOXL2 (0.31) | LOXL2 | |
| SCHEMBL20486385 | 0.71 | — | — | |
| SCHEMBL20487021 | 0.71 | PRMT6 (0.31) | KDM4E | |
| SCHEMBL8802600 | 0.69 | BCL2 (0.44) | CALM1ALOX5BCL2BCL2L1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |