SCHEMBL20489196

SCHEMBL20489196

CCOC(=O)C1[C@H]2COC[C@@H]12

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPM1B O75688 2/20 0.49
PTPN1 P18031 2/20 0.49
PPP1CC P36873 1/20 0.49
MAPT P10636 2/20 0.39
ALDH1A1 P00352 4/20 0.37
TSHR P16473 3/20 0.37
LMNA P02545 2/20 0.36
POLB P06746 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1614134 1.00 PPM1B (0.49) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL28403234 1.00 PPM1B (0.49) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL16405665 1.00 PPM1B (0.49) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL34472936 0.92 PPM1B (0.46) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL34468392 0.87 PPM1B (0.46) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL32677632 0.81 PPM1B (0.44) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL32677631 0.81 PPM1B (0.44) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL15712143 0.80 PPM1B (0.53) PPM1BPTPN1PPP1CCMAPTALDH1A1
SCHEMBL23780231 0.78
SCHEMBL5778032 0.78 PPM1B (0.43) PPM1BPTPN1PPP1CCMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110582485-B Pyrazole derivatives as bromodomain inhibitors 葛兰素史克知识产权第二有限公司 2023-10-13 CN disclosed
EP-3589618-B1 PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2022-12-28 EP disclosed
EP-3692026-B1 BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS. GLAXOSMITHKLINE IP NO 2 LTD (GB) 2022-07-06 EP disclosed
US-11319307-B2 2,3-dihydrobenzohurans as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2022-05-03 US disclosed
US-11273146-B2 Benzofuran derivatives and their use as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2022-03-15 US disclosed
US-10966961-B2 Pyrazole derivatives as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2021-04-06 US disclosed
US-10934272-B2 Pyridyl derivatives as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2021-03-02 US disclosed
EP-3440069-B1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-10-28 EP disclosed
US-20200289464-A1 BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2020-09-17 US disclosed
US-20200291009-A1 2,3-DIHYDROBENZOFURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2020-09-17 US disclosed
US-10583112-B2 Benzo[b]furans as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2020-03-10 US disclosed
EP-3440075-B1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-01-29 EP disclosed
US-10370356-B2 Pyridinone dicarboxamide for use as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-08-06 US disclosed
US-20190151279-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-05-23 US disclosed
US-20190119248-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-04-25 US disclosed
US-20180282301-A1 PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2018-10-04 US disclosed
WO-2018158212-A1 PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2018-09-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10370356-B2 Pyridinone dicarboxamide for use as bromodomain inhibitors BRD4, BRD3, BRDT PPM1B 1176/4885PTPN1 2541/4885PPP1CC 3358/4885
US-20200289464-A1 BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRPF3 PPM1B 2100/4885PTPN1 4220/4885PPP1CC 3963/4885
US-10966961-B2 Pyrazole derivatives as bromodomain inhibitors BRD3, BRD4, BRPF3 PPM1B 465/4885PTPN1 2285/4885PPP1CC 2105/4885
US-10934272-B2 Pyridyl derivatives as bromodomain inhibitors BRD4, BRD3, BRDT PPM1B 497/4885PTPN1 1850/4885PPP1CC 3032/4885
US-10583112-B2 Benzo[b]furans as bromodomain inhibitors BRD4, BRD3, BRD2 PPM1B 490/4885PTPN1 2957/4885PPP1CC 3254/4885
US-11273146-B2 Benzofuran derivatives and their use as bromodomain inhibitors BRD4, BRD3, BRPF3 PPM1B 2100/4885PTPN1 4220/4885PPP1CC 3963/4885
US-20200291009-A1 2,3-DIHYDROBENZOFURANS AS BROMODOMAIN INHIBITORS BRD4, BRPF3, BRD3 PPM1B 1367/4885PTPN1 3405/4885PPP1CC 3865/4885
US-20190119248-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRDT PPM1B 497/4885PTPN1 1850/4885PPP1CC 3032/4885
US-20190151279-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRD2 PPM1B 490/4885PTPN1 2957/4885PPP1CC 3254/4885
US-20180282301-A1 PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRDT PPM1B 1176/4885PTPN1 2541/4885PPP1CC 3358/4885
US-11319307-B2 2,3-dihydrobenzohurans as bromodomain inhibitors BRD4, BRD3, BRPF3 PPM1B 1214/4885PTPN1 3470/4885PPP1CC 4007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.