SCHEMBL2048985

SCHEMBL2048985

Nc1cccc2c1-c1ccccc1C2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
KDM4E B2RXH2 1/20 0.48
NPC1 O15118 1/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
RAB9A P51151 1/20 0.48
MAOA P21397 2/20 0.46
HTR2B P41595 1/20 0.46
ADORA2A P29274 2/20 0.45
PTPRC P08575 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44
POLB P06746 1/20 0.42
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
CSNK1A1 P48729 3/20 0.40
DYRK1A Q13627 3/20 0.40
PIM1 P11309 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29490146 1.00 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
Hydrochloric Acid SCHEMBL2860818 0.98 HTR2B (0.49) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL30297184 0.98 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL21709330 0.98 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
Biphenyl SCHEMBL21611806 0.92 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL30681697 0.88 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL18847838 0.88 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL20823399 0.88 MAOA (0.57) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL10782961 0.84 MAOA (0.61) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA
SCHEMBL10596221 0.84 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2KDM4ENPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114213374-B Synthesis method of 4-aminofluorene 棓诺(苏州)新材料有限公司 2024-05-31 CN claimed
CN-102482436-B Matte finish polyimide films and methods relating thereto DU PONT 2015-03-11 CN claimed
CN-101341115-B 4-aminofluorene compound and organic light emitting device CANON KK 2013-03-06 CN claimed
EP-1966124-B1 4-AMINOFLUORENE COMPOUNDS AND ORGANIC LIGHT EMITTING DEVICES CANON KK (JP) 2012-11-07 EP claimed
CN-102549075-A Filled polyimides and methods related thereto DU PONT 2012-07-04 CN claimed
CN-102482436-A Matte finish polyimide films and methods relating thereto DU PONT 2012-05-30 CN claimed
US-20100033081-A1 4-AMINOFLUORENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2010-02-11 US claimed
CN-101341115-A 4-aminofluorene compound and organic light emitting device CANON KK (JP) 2009-01-07 CN claimed
EP-1966124-A1 4-AMINOFLUORENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE Canon Kabushiki Kaisha (JP) 2008-09-10 EP claimed
WO-2007072952-A1 4-AMINOFLUORENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2007-06-28 WO claimed
EP-0521904-B1 MODIFICATION OF POLYMER SURFACES DU PONT (US) 1998-12-09 EP claimed
EP-0521904-A1 MODIFICATION OF POLYMER SURFACES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-01-13 EP claimed
WO-1991014730-A1 MODIFICATION OF POLYMER SURFACES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO claimed
US-5051312-A Contacting a polymer with a modifier while irradiating with actinic radiation to form a pattern E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-09-24 US claimed
CN-119451453-A Display device 株式会社半导体能源研究所 2025-02-14 CN disclosed
CN-119264174-A Organic compound, light-emitting device, light-emitting apparatus, electronic device, and lighting apparatus 株式会社半导体能源研究所 2025-01-07 CN disclosed
CN-119101024-A Organic compound and light-emitting device 株式会社半导体能源研究所 2024-12-10 CN disclosed
US-4436745-A TETRACYCLIC SPIROHYDANTOINS ALCON LABORATORIES, INC. (US) 1984-03-13 US disclosed
WO-1983003543-A1 METHOD OF INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOROFLUOREN AND SPIRO-DIFLUOROFLUOREN COMPOUNDS ALCON LAB INC (US) 1983-10-27 WO disclosed
EP-0092385-A2 Hydantoin derivatives for use in inhibiting aldose reductase activity, compositions therefor and process for preparing spiro-fluoren compounds ALCON LABORATORIES, INC. (US) 1983-10-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100033081-A1 4-AMINOFLUORENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE ALAD, CYP4F12, CYP4F11 ALDH1A1 52/4885SMN1; SMN2 4229/4885KDM4E 1476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.