Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SOD1 | P00441 | 2/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490494 | 0.91 | QPCT (0.55) | QPCTPOLBTBXAS1CYP19A1SMN1; SMN2 | |
| SCHEMBL10852494 | 0.84 | QPCT (0.73) | QPCTPOLBTBXAS1CYP19A1SMN1; SMN2 | |
| SCHEMBL11495035 | 0.81 | SOD1 (0.67) | QPCTCYP19A1SMN1; SMN2SOD1NPC1 | |
| SCHEMBL20490242 | 0.81 | HDAC4 (0.55) | POLBRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL20490279 | 0.78 | HDAC4 (0.58) | POLBSMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL20490468 | 0.76 | TACR2 (0.58) | POLBSMN1; SMN2CACNA1BNPC1RAB9A | |
| SCHEMBL20490428 | 0.76 | HDAC4 (0.53) | SMN1; SMN2RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL27798451 | 0.76 | HDAC8 (0.55) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20490365 | 0.76 | MALT1 (0.51) | POLBNPC1RAB9AHDAC3HDAC4 | |
| SCHEMBL20490192 | 0.75 | HDAC3 (0.54) | POLBHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |