Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | CBX7 | O95931 | 1/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625952 | 0.71 | LMNA (0.48) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL625846 | 0.71 | MAOB (0.43) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL12867047 | 0.70 | MAOB (0.51) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL626452 | 0.70 | PGR (0.42) | MAOBPGRPPARGLMNAHTR1A | |
| SCHEMBL28967652 | 0.67 | MAOB (0.62) | MAOBPGRLMNA | |
| SCHEMBL627485 | 0.67 | MAOB (0.39) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL12881773 | 0.64 | MAOB (0.52) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL11602317 | 0.64 | BLM (0.51) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL12727792 | 0.64 | MAOB (0.55) | MAOBPGRLMNAHTR1ADRD2 | |
| SCHEMBL10146389 | 0.64 | GRM2 (0.59) | PPARGP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-B1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME (US) | 2018-09-19 | — | — | EP | claimed |