Sugi Predict

Sugi Predict / Compounds / SCHEMBL20500985

SCHEMBL20500985

SCHEMBL20500985

Nc1ncc(-c2cccc(NC(=O)Nc3cc(Cl)nc(Cl)c3)c2)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SCN9A Q15858 2/20 0.53
▸ SCN4A P35499 1/20 0.53
▸ SCN3A Q9NY46 1/20 0.53
▸ S1PR2 O95136 1/20 0.49
▸ CNR1 P21554 8/20 0.46
▸ CNR2 P34972 2/20 0.44
▸ MASP2 O00187 1/20 0.43
▸ BRAF P15056 1/20 0.43
▸ MGLL Q99685 1/20 0.43
▸ KDR P35968 1/20 0.42
▸ VHL P40337 1/20 0.42
▸ PRKD3 O94806 1/20 0.42
▸ MAP4K4 O95819 1/20 0.42
▸ NTRK1 P04629 1/20 0.42
▸ PDGFRB P09619 1/20 0.42
▸ PDGFRA P16234 1/20 0.42
▸ PRKACA P17612 1/20 0.42
▸ LTK P29376 1/20 0.42
▸ CSNK1A1 P48729 1/20 0.42
▸ CDK8 P49336 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20501030 0.90 SCN9A (0.61) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501025 0.89 SCN4A (0.54) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501140 0.88 SCN9A (0.53) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20500998 0.87 SCN9A (0.53) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501013 0.87 CNR1 (0.61) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501076 0.87 SCN9A (0.61) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501144 0.86 CNR1 (0.54) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501016 0.86 SCN9A (0.55) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20501157 0.85 SCN9A (0.57) SCN9ASCN4ASCN3ACNR1CNR2
SCHEMBL20500939 0.84 MAPT (0.56) SCN9ASCN4ASCN3ACNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth NORTH CAROLINA STATE UNIVERSITY (US) 2023-02-21 — — US disclosed
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-01-06 — — US disclosed
CN-110740645-A 2-aminoimidazole-phenyl derivatives for controlling microbial growth 北卡罗莱纳州立大学 2020-01-31 — — CN disclosed
WO-2018169752-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NORTH CAROLINA STATE UNIVERSITY (US) 2018-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth DDC, IL4I1, ING2 SCN9A 4811/4885SCN4A 4688/4885SCN3A 4795/4885
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH DDC, IL4I1, ING2 SCN9A 4811/4885SCN4A 4688/4885SCN3A 4795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.