Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30277721 | 1.00 | RAB9A (0.72) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL25414592 | 0.84 | RAB9A (1.00) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL32682840 | 0.84 | RAB9A (1.00) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL12609646 | 0.84 | RAB9A (0.73) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL1791855 | 0.82 | ALDH1A1 (0.67) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL30277607 | 0.81 | MAPT (0.70) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL24176868 | 0.79 | MAPT (0.71) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL10653352 | 0.78 | MAPT (0.52) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL18394406 | 0.76 | RAB9A (0.62) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL12349885 | 0.76 | NPC1 (0.76) | RAB9AALDH1A1NPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018169752-A1 | 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH | NORTH CAROLINA STATE UNIVERSITY (US) | 2018-09-20 | — | — | WO | disclosed |