Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LIPA | P38571 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31111632 | 1.00 | ALDH1A1 (0.51) | ALDH1A1POLBLIPASMN1; SMN2MAPT | |
| SCHEMBL30531443 | 0.86 | CYP3A4 (0.41) | ALDH1A1POLBSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL30605886 | 0.76 | CYP3A4 (0.35) | ALDH1A1SMN1; SMN2MAPTCYP3A4TSHR | |
| SCHEMBL30678682 | 0.75 | ALDH1A1 (0.50) | ALDH1A1POLBLIPASMN1; SMN2MAPT | |
| SCHEMBL27852103 | 0.74 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27478065 | 0.74 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL30473912 | 0.74 | ALDH1A1 (0.56) | ALDH1A1POLBLIPASMN1; SMN2MAPT | |
| SCHEMBL970704 | 0.72 | RBP4 (0.50) | ALDH1A1SMN1; SMN2HPGDMAPK1GAA | |
| SCHEMBL2053535 | 0.72 | RBBP9 (0.53) | POLBSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3559527 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |