Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.61 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 10/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 2/20 | 0.45 |
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.45 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.45 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107279 | 1.00 | PLK1 (0.61) | PLK1RARBTHRBTHRAKDM6B | |
| SCHEMBL11679369 | 0.81 | THRB (0.57) | PLK1THRBTHRAKDM6BKDM4A | |
| SCHEMBL12080799 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL22438945 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL6487501 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL7829330 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL9365114 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL28477008 | 0.80 | THRA (0.62) | PLK1RARBTHRBTHRA | |
| SCHEMBL10660017 | 0.79 | MCL1 (0.63) | PLK1THRBTHRAKDM6BKDM4A | |
| SCHEMBL22075766 | 0.78 | ESR1 (0.49) | PLK1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377473-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2024-06-19 | — | — | EP | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| CN-108884058-B | Macrocyclic broad spectrum antibiotics | 阿奇克斯制药公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-108884058-A | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | 阿奇克斯制药公司 | 2018-11-23 | — | — | CN | disclosed |
| US-20180327367-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | WUXI APPTEC CO., LTD (CN) | 2018-11-15 | — | — | US | disclosed |
| EP-3377473-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX Pharmaceuticals, Inc. (US) | 2018-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180327367-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | PLK1 1460/4885RARB 1554/4885THRB 2804/4885 |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | PLK1 1460/4885RARB 1554/4885THRB 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.