Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326604 | 0.90 | MMP8 (0.53) | MMP8TSHRTDP1ALDH1A1TP53 | |
| SCHEMBL7696784 | 0.88 | ESR1 (0.51) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL3764833 | 0.87 | MMP8 (0.50) | MMP8TSHRTDP1ALDH1A1TP53 | |
| SCHEMBL2429506 | 0.87 | PPARG (0.50) | MMP8MAPK1TDP1ALDH1A1TP53 | |
| SCHEMBL901733 | 0.87 | EPHX2 (0.50) | MMP8TSHRALDH1A1TP53NPY1R | |
| SCHEMBL2426124 | 0.87 | MMP8 (0.54) | MMP8MAPK1ALDH1A1TP53NPY1R | |
| SCHEMBL856250 | 0.86 | MMP8 (0.69) | MMP8TSHRMAPK1L3MBTL1TDP1 | |
| SCHEMBL4849611 | 0.86 | PTPRB (0.51) | MMP8L3MBTL1TDP1ALDH1A1LDHA | |
| SCHEMBL9231249 | 0.86 | MMP8 (0.50) | MMP8TSHRMAPK1TDP1ALDH1A1 | |
| SCHEMBL854302 | 0.85 | LDHA (0.63) | MMP8TSHRMAPK1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956041-B2 | antidiabetic mixture contains an inhibitor of renal glucose reabsorption and a hypoglycemic agent; controlling blood glucose level; tolbutamide, chlorpropamide, glibenclamide, glipizide, glimepiride, and gliclazide; metformin, phenformin and buformin; repaglinide, nateglinide and mitiglinide | AJINOMOTO CO., INC. (JP) | 2011-06-07 | — | — | US | disclosed |
| EP-2163555-A1 | New pyrazole derivatives and diabetic medicine containing them | Ajinomoto Co., Inc. (JP) | 2010-03-17 | — | — | EP | disclosed |
| US-20100063124-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | AJINOMOTO CO., INC. (JP) | 2010-03-11 | — | — | US | disclosed |
| US-7645787-B2 | Pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO., INC. (JP) | 2010-01-12 | — | — | US | disclosed |
| US-20070270479-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | AJINOMOTO CO. INC (JP) | 2007-11-22 | — | — | US | disclosed |
| US-7256209-B2 | Pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO., INC. (JP) | 2007-08-14 | — | — | US | disclosed |
| US-7247616-B2 | Pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO., INC. (JP) | 2007-07-24 | — | — | US | disclosed |
| US-20070099979-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | AJINOMOTO CO. INC (JP) | 2007-05-03 | — | — | US | disclosed |
| US-7015201-B2 | Pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO., INC. (JP) | 2006-03-21 | — | — | US | disclosed |
| US-20060058244-A1 | New pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO. INC (JP) | 2006-03-16 | — | — | US | disclosed |
| US-20050143424-A1 | Prophylactic and therapeutic agent of diabetes mellitus | AJINOMOTO CO. INC (JP) | 2005-06-30 | — | — | US | disclosed |
| US-20050043249-A1 | New pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO. INC (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1500403-A1 | PREVENTIVE/REMEDY FOR DIABETES | Ajinomoto Co., Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-6815428-B2 | AS DIABETIC-MEDICINE WHICH IS EASY TO SYNTHESIZE, LESS TOXIC AND HAS HIGHER CURATIVE EFFECT | AJINOMOTO CO., INC. (JP) | 2004-11-09 | — | — | US | disclosed |
| US-20040006025-A1 | Pyrazole derivatives and diabetic medicine containing them | AJINOMOTO CO. INC (JP) | 2004-01-08 | — | — | US | disclosed |
| EP-1338603-A1 | NOVEL PYRAZOLE DERIVATIVES AND DIABETES REMEDIES CONTAINING THE SAME | Ajinomoto Co., Inc. (JP) | 2003-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006025-A1 | Pyrazole derivatives and diabetic medicine containing them | SLC5A2, SLC5A1, DPP4 | MMP8 1175/4885TSHR 2734/4885MAPK1 1651/4885 |
| US-20070270479-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | DPP4, SLC5A2, SLC5A1 | MMP8 2536/4885TSHR 2791/4885MAPK1 1638/4885 |
| US-20070099979-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | DPP4, SLC5A2, SLC5A1 | MMP8 2536/4885TSHR 2791/4885MAPK1 1638/4885 |
| US-20060058244-A1 | New pyrazole derivatives and diabetic medicine containing them | DPP4, SLC5A2, SLC5A1 | MMP8 2536/4885TSHR 2791/4885MAPK1 1638/4885 |
| US-20100063124-A1 | NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM | DPP4, SLC5A2, SLC5A1 | MMP8 2536/4885TSHR 2791/4885MAPK1 1638/4885 |
| US-20050043249-A1 | New pyrazole derivatives and diabetic medicine containing them | DPP4, SLC5A2, SLC5A1 | MMP8 2536/4885TSHR 2791/4885MAPK1 1638/4885 |
| US-20050143424-A1 | Prophylactic and therapeutic agent of diabetes mellitus | SLC5A2, SLC5A1, GPR119 | MMP8 1675/4885TSHR 3004/4885MAPK1 3307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.