Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Catechol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL20590989 | 0.85 | CA2 (0.53) | LMNACA2CYP3A4ALOX15MAPT | |
| Catechol SCHEMBL20590986 | 0.83 | CA2 (0.50) | LMNACA2CYP3A4ALOX15MAPT | |
| Catechol SCHEMBL20590979 | 0.83 | CA2 (0.50) | LMNACA2CYP3A4ALOX15MAPT | |
| Catechol SCHEMBL20590988 | 0.83 | CA2 (0.50) | LMNACA2CYP3A4ALOX15MAPT | |
| Catechol SCHEMBL2279087 | 0.81 | ALDH1A1 (0.59) | TAAR1LMNACA2CYP3A4ALOX15 | |
| Catechol SCHEMBL20590995 | 0.79 | CA2 (0.46) | LMNACA2CYP3A4ALOX15MAPT | |
| Catechol SCHEMBL3985412 | 0.77 | ALDH1A1 (0.53) | TAAR1LMNACA2CYP3A4ALOX15 | |
| Catechol SCHEMBL8565660 | 0.74 | ALDH1A1 (0.43) | TAAR1LMNACA2CYP3A4ALOX15 | |
| Catechol SCHEMBL20508249 | 0.72 | TSHR (0.44) | TAAR1LMNACA2CYP3A4ALOX15 | |
| Orthocresol SCHEMBL10797190 | 0.71 | TAAR1 (0.45) | TAAR1LMNACA2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662291-B2 | Nano-silica hybrid vinyl phenyl silicon intermediate, preparation method thereof and use thereof in environmentally-friendly insulating varnish | SUZHOU TAIHU ELECTRIC ADVANCED MAT CO LTD (CN) | 2020-05-26 | — | — | US | claimed |
| US-20180273686-A1 | NANO-SILICA HYBRID VINYL PHENYL SILICON INTERMEDIATE, PREPARATION METHOD THEREOF AND USE THEREOF IN ENVIRONMENTALLY-FRIENDLY INSULATING VARNISH | SUZHOU TAIHU ELECTRIC ADVANCED MATERIAL CO, LTD. | 2018-09-27 | — | — | US | claimed |
| US-10662291-B2 | Nano-silica hybrid vinyl phenyl silicon intermediate, preparation method thereof and use thereof in environmentally-friendly insulating varnish | SUZHOU TAIHU ELECTRIC ADVANCED MAT CO LTD (CN) | 2020-05-26 | — | — | US | disclosed |
| US-20180273686-A1 | NANO-SILICA HYBRID VINYL PHENYL SILICON INTERMEDIATE, PREPARATION METHOD THEREOF AND USE THEREOF IN ENVIRONMENTALLY-FRIENDLY INSULATING VARNISH | SUZHOU TAIHU ELECTRIC ADVANCED MATERIAL CO, LTD. | 2018-09-27 | — | — | US | disclosed |