Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propranolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 0.85 |
| ▸ | ADRB1 known ✓ | P08588 | 7/20 | 0.85 |
| ▸ | HTR1A | P08908 | 12/20 | 0.85 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.85 |
| ▸ | LMNA | P02545 | 4/20 | 0.85 |
| ▸ | HTR2C | P28335 | 4/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.85 |
| ▸ | TSHR | P16473 | 3/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.85 |
| ▸ | DRD3 | P35462 | 3/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.85 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.85 |
| ▸ | BLM | P54132 | 2/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.85 |
| ▸ | TP53 | P04637 | 2/20 | 0.85 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.85 |
| ▸ | HTR1B | P28222 | 2/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propranolol SCHEMBL540824 | 0.99 | HTR1A (0.87) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL561162 | 0.93 | HTR1A (0.97) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL29379249 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL29908300 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL1157556 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL5219 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL1157882 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL5220 | 0.92 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL2991558 | 0.91 | HTR1A (0.97) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Levopropranolol SCHEMBL41689 | 0.89 | ADRB2 (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662148-B2 | Selective androgen receptor modulator and methods of use thereof | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2020-05-26 | — | — | US | disclosed |
| US-20180273470-A1 | SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2018-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662148-B2 | Selective androgen receptor modulator and methods of use thereof | AR, MUSK, FSHR | ADRB2 324/4885ADRB1 201/4885HTR1A 824/4885 |
| US-20180273470-A1 | SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF | AR, MUSK, FSHR | ADRB2 324/4885ADRB1 201/4885HTR1A 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.