Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 6/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.44 |
| ▸ | PRKCI | P41743 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28188383 | 0.91 | HRH3 (0.49) | PRKCZPRKD2PRKCIRPS6KB1IRAK4 | |
| SCHEMBL28188382 | 0.91 | HRH3 (0.49) | PRKCZPRKD2PRKCIRPS6KB1IRAK4 | |
| SCHEMBL29779677 | 0.82 | S1PR1 (0.52) | — | |
| SCHEMBL23304369 | 0.82 | MALT1 (0.52) | — | |
| SCHEMBL29501368 | 0.81 | HRH3 (0.58) | ROCK2ROCK1CDC42BPBAURKARPS6KB1 | |
| SCHEMBL4006284 | 0.81 | HRH3 (0.58) | ROCK2ROCK1CDC42BPBAURKARPS6KB1 | |
| SCHEMBL7764412 | 0.80 | S1PR1 (0.55) | — | |
| SCHEMBL4705576 | 0.80 | IRAK4 (0.52) | PRKCZPRKD2AURKARPS6KB1IRAK4 | |
| SCHEMBL1671847 | 0.78 | MALT1 (0.58) | IRAK4 | |
| SCHEMBL15219316 | 0.78 | BRD4 (0.53) | PRKCZROCK2ROCK1CDC42BPBCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365809-B1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMA INC (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-3210609-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2017-08-30 | — | — | EP | disclosed |
| CN-102695706-A | Imidazopyridine derivatives as JAK inhibitors | ALMIRALL SA | 2012-09-26 | — | — | CN | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |