SCHEMBL4006284

SCHEMBL4006284

c1cc(NC2CCNCC2)ncn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.58
MAPK1 P28482 1/20 0.50
MALT1 Q9UDY8 1/20 0.49
CYP1A2 P05177 7/20 0.48
ALDH1A1 P00352 3/20 0.48
HSD17B10 Q99714 3/20 0.48
ALOX15 P16050 2/20 0.48
USP2 O75604 2/20 0.48
HIF1A Q16665 1/20 0.48
CYP2C19 P33261 3/20 0.45
CYP3A4 P08684 3/20 0.45
MEN1 O00255 1/20 0.45
CYP2D6 P10635 1/20 0.45
KMT2A Q03164 1/20 0.45
CYP2C9 P11712 1/20 0.44
TDP1 Q9NUW8 1/20 0.43
ROCK2 O75116 1/20 0.43
ROCK1 Q13464 1/20 0.43
CDC42BPB Q9Y5S2 1/20 0.43
HRH4 Q9H3N8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29501368 1.00 HRH3 (0.58) HRH3MAPK1MALT1CYP1A2ALDH1A1
SCHEMBL28188382 0.90 HRH3 (0.49) HRH3MAPK1MALT1HRH4IRAK4
SCHEMBL28188383 0.90 HRH3 (0.49) HRH3MAPK1MALT1HRH4IRAK4
SCHEMBL1671847 0.87 MALT1 (0.58) HRH3MALT1CYP1A2ALDH1A1HSD17B10
SCHEMBL23304369 0.84 MALT1 (0.52) HRH3MALT1ALDH1A1MEN1KMT2A
SCHEMBL29779677 0.84 S1PR1 (0.52) MALT1ALDH1A1MEN1KMT2AHRH4
SCHEMBL7764412 0.82 S1PR1 (0.55) MALT1ALDH1A1MEN1KMT2AS1PR1
SCHEMBL2051027 0.81 PRKCZ (0.50) ROCK2ROCK1CDC42BPBIRAK4AURKA
SCHEMBL25426946 0.79 MAPK1 (0.51) MAPK1MALT1CYP1A2ALDH1A1HSD17B10
SCHEMBL14520680 0.79 MALT1 (0.52) HRH3MALT1CYP1A2ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2861588-A2 NOVEL THERAPEUTICS FOR BRAIN CANCER The Regents of The University of California (US) 2015-04-22 EP claimed
WO-2013188813-A2 NOVEL THERAPEUTICS FOR BRAIN CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-12-19 WO claimed
EP-2043655-A2 PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS Astex Therapeutics Limited (GB) 2009-04-08 EP disclosed
WO-2007125321-A2 PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS ASTEX THERAPEUTICS LIMITED (GB) 2007-11-08 WO disclosed
US-6300333-B1 COMPOUNDS AS FUNGICIDES, MITICIDES OR INSECTICIDES HOECHST SCHERING AGREVO GMBH (DE) 2001-10-09 US disclosed
EP-1068197-A1 SUBSTITUTED PIPERIDINES, METHOD FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES Aventis CropScience GmbH (DE) 2001-01-17 EP disclosed
WO-1999051589-A1 SUBSTITUTED PIPERIDINES, METHOD FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES AVENTIS CROPSCIENCE GMBH (DE) 1999-10-14 WO disclosed