Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 17/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2049741 | 0.99 | TPSAB1 (0.55) | TPSAB1KCNH2CYP2C9CYP2C19HRH2 | |
| SCHEMBL2052560 | 0.94 | TPSAB1 (0.56) | TPSAB1KCNH2CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL2051625 | 0.93 | TPSAB1 (0.55) | TPSAB1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL2052395 | 0.87 | TPSAB1 (0.49) | TPSAB1HRH2 | |
| SCHEMBL10064550 | 0.85 | TPSAB1 (0.55) | TPSAB1KCNH2CYP2C9CYP2C19HRH2 | |
| Hydrochloric Acid SCHEMBL1275313 | 0.85 | TPSAB1 (0.54) | TPSAB1KCNH2CYP2C9CYP2C19HRH2 | |
| SCHEMBL2050593 | 0.84 | TPSAB1 (0.54) | TPSAB1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL12540080 | 0.84 | TPSAB1 (0.44) | TPSAB1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL12642992 | 0.84 | TPSAB1 (0.51) | TPSAB1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL6870911 | 0.84 | TPSAB1 (0.53) | TPSAB1KCNH2CYP2C9CYP2C19HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519520-A1 | [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLOPYRIDINYL)-METHANONE DERIVATIVES AS TRYPTASE INHIBITORS | SANOFI (FR) | 2012-11-07 | — | — | EP | claimed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | claimed |
| WO-2011078984-A1 | [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2011-06-30 | — | — | WO | claimed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| WO-2011078984-A1 | [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245199-A1 | [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF | CMA1, TPSB2, TPH1 | TPSAB1 4/4885KCNH2 1976/4885CYP2C9 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.