Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175734 | 0.88 | PSMB5 (0.79) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7071941 | 0.83 | PSMB5 (0.71) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20515329 | 0.83 | PSMB5 (0.71) | PSMB5MEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL22919305 | 0.83 | PSMB5 (0.71) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20515351 | 0.80 | PSMB5 (1.00) | PSMB5MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL20515387 | 0.80 | PSMB5 (0.67) | PSMB5ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL28788700 | 0.78 | PSMB5 (0.64) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL18676836 | 0.77 | PSMB5 (0.63) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28529940 | 0.76 | PDE10A (0.73) | PSMB5MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL19285631 | 0.76 | PSMB5 (0.60) | PSMB5MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2022-02-17 | — | — | US | disclosed |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2020-11-05 | — | — | US | disclosed |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | NATIONAL SCIENCE FOUNDATION | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | PSMB5 4/4885MEN1 2830/4885KMT2A 775/4885 |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885MEN1 2830/4885KMT2A 775/4885 |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885MEN1 2830/4885KMT2A 775/4885 |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | PSMB5 4/4885MEN1 2830/4885KMT2A 775/4885 |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885MEN1 2830/4885KMT2A 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.