Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 0.71 |
| ▸ | PRNP | P04156 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20515344 | 0.83 | PSMB5 (1.00) | PSMB5ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7071941 | 0.80 | PSMB5 (0.71) | PSMB5ALDH1A1MEN1KMT2AATM | |
| SCHEMBL1786939 | 0.80 | PSMB5 (0.45) | PSMB5PRNPRXFP1PPARGNR2E3 | |
| SCHEMBL790060 | 0.80 | FGFR1 (0.54) | PSMB5PRNPRXFP1ADORA3ADORA2A | |
| SCHEMBL22919305 | 0.80 | PSMB5 (0.71) | PSMB5ALDH1A1MEN1KMT2AATM | |
| SCHEMBL15646572 | 0.80 | HPGD (0.54) | PSMB5PRNPRXFP1ALDH1A1MEN1 | |
| SCHEMBL28175734 | 0.79 | PSMB5 (0.79) | PSMB5ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL28536639 | 0.78 | PDE10A (0.69) | PSMB5PRNPRXFP1PPARGNR2E3 | |
| SCHEMBL20515351 | 0.78 | PSMB5 (1.00) | PSMB5MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL20515387 | 0.78 | PSMB5 (0.67) | PSMB5ALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269720-B | Acetyl-coa synthetase short chain2(ACSS2) Small molecule inhibitors of (a) | 库拉德夫制药私人有限公司 | 2025-03-28 | — | — | CN | disclosed |
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220298115-A1 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | CURADEV PHARMA PVT. LTD. (IN) | 2022-09-22 | — | — | US | disclosed |
| EP-4003961-A2 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | Curadev Pharma Pvt. Ltd. (IN) | 2022-06-01 | — | — | EP | disclosed |
| CN-114269720-A | acetyl-CoA synthetase short chains2(ACSS2) Small molecule inhibitors of | 库拉德夫制药私人有限公司 | 2022-04-01 | — | — | CN | disclosed |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2022-02-17 | — | — | US | disclosed |
| WO-2021014415-A2 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | CURADEV PHARMA PVT. LTD. (IN) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021014415-A2 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | CURADEV PHARMA PVT. LTD. (IN) | 2021-01-28 | — | — | WO | disclosed |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2020-11-05 | — | — | US | disclosed |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | NATIONAL SCIENCE FOUNDATION | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | PSMB5 4/4885PRNP 1652/4885RXFP1 4105/4885 |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885PRNP 1652/4885RXFP1 4105/4885 |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885PRNP 1652/4885RXFP1 4105/4885 |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | PSMB5 4/4885PRNP 1652/4885RXFP1 4105/4885 |
| US-20220298115-A1 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | ACSS2, ACAT1, FADS1 | PSMB5 2946/4885PRNP 1791/4885RXFP1 4631/4885 |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | PSMB5 4/4885PRNP 1652/4885RXFP1 4105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.