Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.51 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548632 | 0.82 | SCN10A (0.42) | CYP1A2TRPV1MEN1NPC1MAPT | |
| SCHEMBL23479219 | 0.77 | ALDH1A1 (0.47) | PSMB5PDGFRBPDGFRACYP1A2TRPV1 | |
| SCHEMBL418110 | 0.77 | CYP1A2 (0.57) | EGFRPDGFRBPDGFRACYP1A2TRPV1 | |
| SCHEMBL23478912 | 0.76 | HRH4 (0.38) | PDGFRBPDGFRATRPV1PDE3BPDE3A | |
| SCHEMBL23479353 | 0.76 | TNKS (0.40) | PDGFRBPDGFRATRPV1PDE3BPDE3A | |
| SCHEMBL19798873 | 0.74 | TERT (0.47) | EGFRPSMB5TERTAPPCYP1A2 | |
| SCHEMBL16203494 | 0.73 | PDGFRB (0.55) | EGFRPDGFRBPDGFRACYP1A2MEN1 | |
| SCHEMBL14072408 | 0.73 | NPC1 (0.38) | PSMB5TRPV1MEN1NPC1MAPT | |
| SCHEMBL1695518 | 0.73 | TRPV1 (0.40) | CYP1A2TRPV1MEN1NPC1MAPT | |
| SCHEMBL25721547 | 0.73 | TERT (0.45) | EGFRPSMB5TERTAPPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2022-02-17 | — | — | US | disclosed |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2020-11-05 | — | — | US | disclosed |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | NATIONAL SCIENCE FOUNDATION | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12084421-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | EGFR 4307/4885PSMB5 4/4885TERT 3197/4885 |
| US-20180282280-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | EGFR 4307/4885PSMB5 4/4885TERT 3197/4885 |
| US-20220048861-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | EGFR 4307/4885PSMB5 4/4885TERT 3197/4885 |
| US-10752590-B2 | Quinoline-based proteasome inhibitors and uses thereof | PSME1, PSMB1, PSME3 | EGFR 4307/4885PSMB5 4/4885TERT 3197/4885 |
| US-20200347019-A1 | QUINOLINE-BASED PROTEASOME INHIBITORS AND USES THEREOF | PSME1, PSMB1, PSME3 | EGFR 4307/4885PSMB5 4/4885TERT 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.