Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 2/20 | 0.48 |
| ▸ | SKP1 | P63208 | 2/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30791110 | 1.00 | ADORA2A (0.53) | ADORA2ACKS1BSKP1SKP2PDE4D | |
| SCHEMBL3753329 | 0.87 | CKS1B (0.45) | ADORA2ACKS1BSKP1SKP2GPR119 | |
| SCHEMBL3760202 | 0.84 | EGLN2 (0.52) | CKS1BSKP1SKP2GPR119MAPT | |
| SCHEMBL902759 | 0.82 | ADORA2A (0.60) | ADORA2ACKS1BSKP1SKP2PDE4D | |
| SCHEMBL1467354 | 0.82 | ALDH1A1 (0.52) | GPR119MAPTPOLB | |
| SCHEMBL16933561 | 0.82 | GPR119 (0.54) | ADORA2ACKS1BSKP1SKP2GPR119 | |
| SCHEMBL6950816 | 0.81 | RET (0.54) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL20516119 | 0.81 | JAK2 (0.53) | ADORA2AJAK2JAK3KIT | |
| SCHEMBL30791072 | 0.81 | JAK2 (0.53) | ADORA2AJAK2JAK3KIT | |
| SCHEMBL3268748 | 0.81 | CKS1B (0.56) | ADORA2ACKS1BSKP1SKP2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110799190-B | Heterocyclic compounds | 卡都瑞恩医药有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-113365632-B | Aminopyrimidine compounds | 卡都瑞恩医药有限公司 | 2024-03-08 | — | — | CN | disclosed |
| EP-3856188-B1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS INC (US) | 2023-06-21 | — | — | EP | disclosed |
| US-20220112184-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC | 2022-04-14 | — | — | US | disclosed |
| US-11197858-B2 | Substituted amines for treating cardiac diseases | CARDURION PHARMACEUTICALS, LLC (US) | 2021-12-14 | — | — | US | disclosed |
| US-11130752-B2 | Aminopyrimidine compound | CARDURION PHARMACEUTICALS, LLC (US) | 2021-09-28 | — | — | US | disclosed |
| CN-113365632-A | Aminopyrimidine compounds | 卡都瑞恩医药有限责任公司 | 2021-09-07 | — | — | CN | disclosed |
| EP-3856188-A1 | AMINOPYRIMIDINE COMPOUND | Cardurion Pharmaceuticals, LLC (US) | 2021-08-04 | — | — | EP | disclosed |
| US-20200230137-A1 | SUBSTITUTED AMINES FOR TREATING CARDIAC DISEASES | CARDURION PHARMACEUTICALS, LLC (US) | 2020-07-23 | — | — | US | disclosed |
| WO-2020068854-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2020-04-02 | — | — | WO | disclosed |
| WO-2020068846-A1 | HETEROCYCLIC COMPOUND | HETEROCYCLIC COMPOUND (US) | 2020-04-02 | — | — | WO | disclosed |
| US-20200095240-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC | 2020-03-26 | — | — | US | disclosed |
| CN-110799190-A | Heterocyclic compounds | 卡都瑞恩医药有限责任公司 | 2020-02-14 | — | — | CN | disclosed |
| EP-3600327-A1 | HETEROCYCLIC COMPOUND | Cardurion Pharmaceuticals, LLC (US) | 2020-02-05 | — | — | EP | disclosed |
| US-10543212-B2 | Substituted amines for treating cardiac diseases | CARDURION PHARMACEUTICALS, LLC (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180280389-A1 | HETEROCYCLIC COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2018-10-04 | — | — | US | disclosed |
| WO-2018183112-A1 | HETEROCYCLIC COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130752-B2 | Aminopyrimidine compound | CALM1, CAMK4, CAMK2B | ADORA2A 1034/4885CKS1B 921/4885SKP1 226/4885 |
| US-11197858-B2 | Substituted amines for treating cardiac diseases | TNNI3, CALM1, CAMK2G | ADORA2A 709/4885CKS1B 1334/4885SKP1 911/4885 |
| US-20180280389-A1 | HETEROCYCLIC COMPOUND | CALM1, CAMK2B, CAMK2G | ADORA2A 2382/4885CKS1B 1196/4885SKP1 241/4885 |
| US-20200095240-A1 | AMINOPYRIMIDINE COMPOUND | CALM1, CAMK4, CAMK2B | ADORA2A 1034/4885CKS1B 921/4885SKP1 226/4885 |
| US-10543212-B2 | Substituted amines for treating cardiac diseases | TNNI3, CALM1, CAMK2G | ADORA2A 709/4885CKS1B 1334/4885SKP1 911/4885 |
| US-20200230137-A1 | SUBSTITUTED AMINES FOR TREATING CARDIAC DISEASES | TNNI3, CALM1, CAMK2G | ADORA2A 709/4885CKS1B 1334/4885SKP1 911/4885 |
| US-20220112184-A1 | AMINOPYRIMIDINE COMPOUND | CALM1, CAMK4, CAMK2B | ADORA2A 1034/4885CKS1B 921/4885SKP1 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.