Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15091298 | 0.83 | PIK3CA (0.37) | HSP90AA1HSP90AB1PIK3CAPIK3CDABL1 | |
| SCHEMBL15091451 | 0.81 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1POLBPIK3CAPIK3CD | |
| SCHEMBL25053114 | 0.80 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1POLBPIK3CAPIK3CD | |
| SCHEMBL25909811 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1POLBPIK3CAPIK3CD | |
| SCHEMBL1396849 | 0.78 | PIK3CD (0.48) | HSP90AA1HSP90AB1POLBPIK3CAPIK3CD | |
| SCHEMBL17714320 | 0.78 | RPS6KA5 (0.36) | EGFRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL24400696 | 0.78 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1POLBPIK3CAMET | |
| SCHEMBL19949248 | 0.77 | ELANE (0.38) | HSP90AA1HSP90AB1POLBEGFRSTK17B | |
| SCHEMBL29913685 | 0.76 | SSTR4 (0.39) | HSP90AA1HSP90AB1PIK3CAPIK3CDABL1 | |
| SCHEMBL29173101 | 0.76 | SSTR4 (0.39) | HSP90AA1HSP90AB1PIK3CAPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| CN-111511744-B | Diazaindole compounds | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |
| US-11299501-B2 | Diazaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-04-12 | — | — | US | disclosed |
| EP-3728264-B1 | DIAZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3728264-B1 | DIAZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3212652-B1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK (CA) | 2021-02-17 | — | — | EP | disclosed |
| US-10875863-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-29 | — | — | US | disclosed |
| EP-3728264-A1 | DIAZAINDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2020-10-28 | — | — | EP | disclosed |
| US-20200308195-A1 | DIAZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-01 | — | — | US | disclosed |
| US-20200308195-A1 | DIAZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-01 | — | — | US | disclosed |
| CN-111511744-A | Diazaindole compounds | 百时美施贵宝公司 | 2020-08-07 | — | — | CN | disclosed |
| US-10239881-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2019-03-26 | — | — | US | disclosed |
| US-20180282335-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282335-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | RIPK2, RIPK1, RIPK4 | HSP90AA1 1672/4885HSP90AB1 1409/4885POLB 3409/4885 |
| US-20200308195-A1 | DIAZAINDOLE COMPOUNDS | TLR7, TLR9, TLR1 | HSP90AA1 3699/4885HSP90AB1 3604/4885POLB 3023/4885 |
| US-10875863-B2 | RIPK2 inhibitors and method of treating cancer with same | RIPK2, RIPK1, RIPK4 | HSP90AA1 1673/4885HSP90AB1 1487/4885POLB 3444/4885 |
| US-10239881-B2 | RIPK2 inhibitors and method of treating cancer with same | RIPK2, RIPK1, RIPK4 | HSP90AA1 1672/4885HSP90AB1 1409/4885POLB 3409/4885 |
| US-11299501-B2 | Diazaindole compounds | TLR7, TLR9, TLR1 | HSP90AA1 3699/4885HSP90AB1 3604/4885POLB 3023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.