Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520865 | 0.96 | MAPT (0.48) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL18736322 | 0.95 | MAPT (0.47) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL20520122 | 0.92 | LMNA (0.47) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL18736253 | 0.91 | MAPT (0.46) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL20759007 | 0.90 | KMT2A (0.50) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL18705316 | 0.89 | RAB9A (0.54) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL31354704 | 0.89 | RAB9A (0.54) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL1968491 | 0.86 | KMT2A (0.55) | PTPN1MAPTLMNAKMT2ANPC1 | |
| SCHEMBL18705337 | 0.85 | PPARD (0.56) | PTPN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL22230427 | 0.85 | KMT2A (0.45) | PTPN1MAPTLMNAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12458706-B2 | Compounds and therapeutic uses thereof | AVVINITY THERAPEUTICS LIMITED (GB) | 2025-11-04 | — | — | US | disclosed |
| EP-3606558-B1 | NOVEL COMPOUNDS AND THERAPEUTIC USES THEREOF | CENTAURI THERAPEUTICS LTD (GB) | 2021-12-15 | — | — | EP | disclosed |
| EP-3606558-B1 | NOVEL COMPOUNDS AND THERAPEUTIC USES THEREOF | CENTAURI THERAPEUTICS LTD (GB) | 2021-12-15 | — | — | EP | disclosed |
| US-20210369850-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | Centauri Therapeutics Limited (GB/GB) (GB) | 2021-12-02 | — | — | US | disclosed |
| US-20210353765-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | AVVINITY THERAPEUTICS LIMITED (GB/GB) (GB) | 2021-11-18 | — | — | US | disclosed |
| US-20210353765-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | AVVINITY THERAPEUTICS LIMITED (GB/GB) (GB) | 2021-11-18 | — | — | US | disclosed |
| US-11130730-B2 | Compounds and therapeutics uses thereof | Centauri Therapeutics Limited (GB/GB) (GB) | 2021-09-28 | — | — | US | disclosed |
| US-11130730-B2 | Compounds and therapeutics uses thereof | Centauri Therapeutics Limited (GB/GB) (GB) | 2021-09-28 | — | — | US | disclosed |
| US-10953100-B2 | Compounds and therapeutic uses thereof | CENTUARI THERAPEUTICS LIMITED (GB/GB) (GB) | 2021-03-23 | — | — | US | disclosed |
| US-10953100-B2 | Compounds and therapeutic uses thereof | CENTUARI THERAPEUTICS LIMITED (GB/GB) (GB) | 2021-03-23 | — | — | US | disclosed |
| US-20200231538-A1 | NOVEL COMPOUNDS AND THERAPEUTICS USES THEREOF | Centauri Therapeutics Limited (GB/GB) (GB) | 2020-07-23 | — | — | US | disclosed |
| US-20200231538-A1 | NOVEL COMPOUNDS AND THERAPEUTICS USES THEREOF | Centauri Therapeutics Limited (GB/GB) (GB) | 2020-07-23 | — | — | US | disclosed |
| US-20180280521-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | CENTUARI THERAPEUTICS LIMITED (GB/GB) (GB) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353765-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MAVS, NFATC1, MYD88 | PTPN1 2402/4885MAPT 2826/4885LMNA 3277/4885 |
| US-20210369850-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | CD47, MYD88, NFATC1 | PTPN1 2681/4885MAPT 2614/4885LMNA 3909/4885 |
| US-12458706-B2 | Compounds and therapeutic uses thereof | MAVS, NFATC1, MYD88 | PTPN1 2402/4885MAPT 2826/4885LMNA 3277/4885 |
| US-11130730-B2 | Compounds and therapeutics uses thereof | MAVS, MYD88, CD47 | PTPN1 2006/4885MAPT 1933/4885LMNA 3126/4885 |
| US-20200231538-A1 | NOVEL COMPOUNDS AND THERAPEUTICS USES THEREOF | MAVS, CD47, STING1 | PTPN1 2495/4885MAPT 2178/4885LMNA 3762/4885 |
| US-10953100-B2 | Compounds and therapeutic uses thereof | CD47, MYD88, NFATC1 | PTPN1 2681/4885MAPT 2614/4885LMNA 3909/4885 |
| US-20180280521-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | CD47, MYD88, NFATC1 | PTPN1 2681/4885MAPT 2614/4885LMNA 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.