Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.79 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.79 |
| ▸ | CFTR | P13569 | 7/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696613 | 1.00 | NR4A2 (0.79) | NR4A2CREBBPCFTRHTR3EHTR3B | |
| SCHEMBL30031033 | 0.88 | NR4A2 (1.00) | NR4A2CREBBPPBRM1RAB9AGPR84 | |
| SCHEMBL1093530 | 0.88 | NR4A2 (1.00) | NR4A2CREBBPPBRM1RAB9AGPR84 | |
| SCHEMBL7515095 | 0.88 | NR4A2 (0.60) | NR4A2CREBBPCFTRHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL28254334 | 0.87 | NR4A2 (0.97) | NR4A2CREBBPPBRM1RAB9AGPR84 | |
| SCHEMBL28306489 | 0.84 | NR4A2 (0.56) | NR4A2CREBBPCFTRHTR3EHTR3B | |
| SCHEMBL376662 | 0.83 | GABRA1 (0.69) | CFTRGABRA1GABRB2 | |
| SCHEMBL29475801 | 0.83 | GABRA1 (0.69) | CFTRGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL29008098 | 0.82 | GABRA1 (0.67) | CFTRGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL30417898 | 0.82 | GABRA1 (0.67) | CFTRGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230263794-A1 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-24 | — | — | US | disclosed |
| CN-111533729-B | Tetrazole-substituted quinolinone derivative and preparation method and application thereof | 盐城工学院 | 2022-07-26 | — | — | CN | disclosed |
| CN-111533729-A | Tetrazole-substituted quinolinone derivative and preparation method and application thereof | 盐城工学院 | 2020-08-14 | — | — | CN | disclosed |
| EP-2509954-A1 | 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072241-A1 | 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230263794-A1 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP4B1, CYP3A4 | NR4A2 581/4885CREBBP 3474/4885CFTR 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.