SCHEMBL20522347

SCHEMBL20522347

COc1ccc(-c2ccccc2NCc2ccc3[nH]cnc3c2)cc1OC

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.48
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 2/20 0.48
MAPT P10636 2/20 0.48
HPGD P15428 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
QPCT Q16769 10/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
QPCTL Q9NXS2 4/20 0.42
MEN1 O00255 2/20 0.42
DYRK1A Q13627 1/20 0.41
CLK4 Q9HAZ1 1/20 0.41
ABCB1 P08183 1/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29550895 1.00 KMT2A (0.48) KMT2AKDM4EALDH1A1LMNAMAPT
SCHEMBL29550590 0.87 ACP1 (0.46) ALDH1A1LMNAMAPTQPCTQPCTL
SCHEMBL22712388 0.87 ACP1 (0.46) ALDH1A1LMNAMAPTQPCTQPCTL
SCHEMBL22712376 0.87 QPCT (0.42) KMT2AKDM4EALDH1A1LMNAMAPT
SCHEMBL29550588 0.87 QPCT (0.42) KMT2AKDM4EALDH1A1LMNAMAPT
SCHEMBL20522274 0.86 SYK (0.49) KMT2AALDH1A1LMNAHPGDQPCT
SCHEMBL29551514 0.86 SYK (0.49) KMT2AALDH1A1LMNAHPGDQPCT
SCHEMBL20522388 0.85 QPCT (0.51) KMT2AKDM4EALDH1A1LMNAMAPT
SCHEMBL29550917 0.85 QPCT (0.51) KMT2AKDM4EALDH1A1LMNAMAPT
SCHEMBL20522455 0.84 KMT2A (0.43) KMT2AKDM4EALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN claimed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 KMT2A 3101/4885KDM4E 1773/4885ALDH1A1 1183/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT KMT2A 2829/4885KDM4E 1119/4885ALDH1A1 1681/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS KMT2A 2908/4885KDM4E 1078/4885ALDH1A1 1490/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 KMT2A 2772/4885KDM4E 1254/4885ALDH1A1 1415/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT KMT2A 2867/4885KDM4E 1160/4885ALDH1A1 1184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.