SCHEMBL20522388

SCHEMBL20522388

COc1ccc(-c2c(C)cccc2NCc2ccc3[nH]cnc3c2)cc1OC

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 9/20 0.51
KMT2A Q03164 3/20 0.43
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 2/20 0.43
HPGD P15428 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MEN1 O00255 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
QPCTL Q9NXS2 3/20 0.40
DYRK1A Q13627 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
ABCB1 P08183 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.39
AMY1A P0DUB6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29550917 1.00 QPCT (0.51) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL29550603 0.89 KMT2A (0.43) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL20522455 0.89 KMT2A (0.43) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL20522291 0.88 QPCTL (0.42) QPCTKMT2AMEN1QPCTLGAA
SCHEMBL29550849 0.88 QPCTL (0.42) QPCTKMT2AMEN1QPCTLGAA
SCHEMBL20522347 0.85 KMT2A (0.48) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL29550895 0.85 KMT2A (0.48) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL22712376 0.78 QPCT (0.42) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL29550588 0.78 QPCT (0.42) QPCTKMT2AKDM4EALDH1A1LMNA
SCHEMBL20522274 0.77 SYK (0.49) QPCTKMT2AALDH1A1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN claimed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 QPCT 6/4885KMT2A 3101/4885KDM4E 1773/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT QPCT 3/4885KMT2A 2829/4885KDM4E 1119/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS QPCT 2/4885KMT2A 2908/4885KDM4E 1078/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 QPCT 2/4885KMT2A 2772/4885KDM4E 1254/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT QPCT 3/4885KMT2A 2867/4885KDM4E 1160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.