SCHEMBL20522381

SCHEMBL20522381

COc1ccc(-c2nccnc2NCc2ccc3[nH]cnc3c2)cc1OC

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 7/20 0.44
DYRK1A Q13627 1/20 0.44
CLK4 Q9HAZ1 1/20 0.44
SYK P43405 3/20 0.44
LMNA P02545 1/20 0.43
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
QPCTL Q9NXS2 3/20 0.42
STAT1 P42224 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
APP P05067 2/20 0.40
PDE5A O76074 1/20 0.39
TNF P01375 1/20 0.39
NOD1 Q9Y239 1/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29551525 1.00 QPCT (0.44) QPCTDYRK1ACLK4SYKLMNA
SCHEMBL29550843 0.87 MAPT (0.44) QPCTDYRK1ACLK4SMN1; SMN2QPCTL
SCHEMBL20522363 0.87 MAPT (0.44) QPCTDYRK1ACLK4SMN1; SMN2QPCTL
SCHEMBL20522274 0.86 SYK (0.49) QPCTDYRK1ACLK4SYKLMNA
SCHEMBL29551514 0.86 SYK (0.49) QPCTDYRK1ACLK4SYKLMNA
SCHEMBL20522358 0.81 QPCT (0.47) QPCTDYRK1ACLK4
SCHEMBL29550383 0.81 QPCT (0.47) QPCTDYRK1ACLK4
SCHEMBL20522347 0.79 KMT2A (0.48) QPCTDYRK1ACLK4LMNASMN1; SMN2
SCHEMBL29550895 0.79 KMT2A (0.48) QPCTDYRK1ACLK4LMNASMN1; SMN2
SCHEMBL22712376 0.79 QPCT (0.42) QPCTDYRK1ACLK4LMNAQPCTL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN claimed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP claimed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 QPCT 6/4885DYRK1A 1140/4885CLK4 3637/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT QPCT 3/4885DYRK1A 1606/4885CLK4 3420/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS QPCT 2/4885DYRK1A 1577/4885CLK4 3825/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 QPCT 2/4885DYRK1A 692/4885CLK4 2808/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT QPCT 3/4885DYRK1A 1632/4885CLK4 3585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.