SCHEMBL20522396

SCHEMBL20522396

COc1ccc(-c2cnccc2Nc2ccc(-c3nnc(N)s3)cc2)cc1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 1/20 0.47
CTDSP1 Q9GZU7 1/20 0.47
QPCT Q16769 3/20 0.45
QPCTL Q9NXS2 3/20 0.45
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 3/20 0.44
HSD17B10 Q99714 2/20 0.44
MAPT P10636 2/20 0.44
TP53 P04637 1/20 0.44
MGAM O43451 1/20 0.42
GAA P10253 1/20 0.42
SI P14410 1/20 0.42
MGAM2 Q2M2H8 1/20 0.42
HPGD P15428 2/20 0.42
PRKCQ Q04759 5/20 0.41
DYRK1A Q13627 1/20 0.40
PIM1 P11309 1/20 0.40
PIM3 Q86V86 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29550815 1.00 MEN1 (0.47) MEN1KMT2APOLBCTDSP1QPCT
SCHEMBL20522382 0.86 ALDH1A1 (0.51) MEN1KMT2APOLBCTDSP1QPCT
SCHEMBL20522383 0.86 KDM4E (0.60) MEN1KMT2APOLBQPCTQPCTL
SCHEMBL20522361 0.83 KDM4E (0.49) MEN1KMT2APOLBCTDSP1ALDH1A1
SCHEMBL28352566 0.80 BLM (0.46) MEN1KMT2APOLBCTDSP1ALDH1A1
SCHEMBL28352563 0.78 HDAC1 (0.54) MEN1KMT2APOLBCTDSP1ALDH1A1
SCHEMBL11334896 0.76 ALDH1A1 (0.63) MEN1KMT2AQPCTQPCTLALDH1A1
SCHEMBL29551207 0.75 PRKCQ (0.44) QPCTMAPTTP53GAAPRKCQ
SCHEMBL22712377 0.75 PRKCQ (0.44) QPCTMAPTTP53GAAPRKCQ
SCHEMBL20522413 0.71 KDM4E (0.64) MEN1KMT2AQPCTQPCTLALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US claimed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP claimed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 MEN1 3715/4885KMT2A 3101/4885POLB 1502/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT MEN1 4443/4885KMT2A 2829/4885POLB 1286/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS MEN1 4170/4885KMT2A 2908/4885POLB 1251/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 MEN1 4216/4885KMT2A 2772/4885POLB 927/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT MEN1 4169/4885KMT2A 2867/4885POLB 1457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.