Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | KDM6B | O15054 | 4/20 | 0.50 |
| ▸ | KDM5C | P41229 | 4/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.50 |
| ▸ | KDM3A | Q9Y4C1 | 4/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | TET3 | O43151 | 1/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.50 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427285 | 0.95 | KDM5C (0.55) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL503171 | 0.95 | KDM5C (0.55) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| Alcohol SCHEMBL28244007 | 0.87 | KDM4C (0.47) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL16094544 | 0.82 | KDM4C (0.53) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL28019417 | 0.82 | VNN1 (0.58) | VNN1SMARCA2SMARCA4LOXL2HDAC4 | |
| SCHEMBL16036217 | 0.81 | KDM4C (0.52) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30893039 | 0.81 | KDM4C (0.52) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL25221330 | 0.79 | VNN1 (0.46) | VNN1SMARCA2SMARCA4LOXL2HDAC4 | |
| SCHEMBL30016958 | 0.79 | SMARCA2 (0.49) | SYKVNN1SMARCA2SMARCA4LOXL2 | |
| SCHEMBL16690807 | 0.79 | SMARCA2 (0.49) | SYKVNN1SMARCA2SMARCA4LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | Pharmakea, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183122-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2018-10-04 | — | — | WO | disclosed |