Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20523784 | 0.98 | LMNA (0.56) | LMNAALDH1A1HPGDCTSKCTSL | |
| SCHEMBL3363757 | 0.98 | LMNA (0.56) | LMNAALDH1A1HPGDCTSKCTSL | |
| SCHEMBL21597702 | 0.92 | LMNA (0.43) | LMNAALDH1A1HPGDKMT2APOLB | |
| SCHEMBL18938837 | 0.92 | LMNA (0.43) | LMNAALDH1A1HPGDKMT2APOLB | |
| SCHEMBL11311502 | 0.80 | LMNA (0.49) | LMNAALDH1A1HPGDCTSKCTSL | |
| SCHEMBL12284997 | 0.78 | LMNA (0.59) | LMNAALDH1A1POLB | |
| SCHEMBL1734351 | 0.77 | LMNA (0.62) | LMNAHPGDKMT2APOLBGAA | |
| SCHEMBL27471005 | 0.77 | LMNA (0.81) | LMNAALDH1A1HPGDKMT2APOLB | |
| SCHEMBL4004096 | 0.75 | LMNA (0.66) | LMNAHPGDKMT2AMAPTSLC1A3 | |
| SCHEMBL9208258 | 0.75 | LMNA (0.85) | LMNAALDH1A1HPGDKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11633415-B2 | Compounds and methods useful for treating or preventing cancers | THE BROAD INSTITUTE, INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20220096513-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | THE BROAD INSTITUTE, INC. (US) | 2022-03-31 | — | — | US | disclosed |
| WO-2018183936-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | THE BROAD INSTITUTE, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096513-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | CSNK1A1, CSNK2A1, CSNK2A3 | LMNA 1021/4885ALDH1A1 626/4885HPGD 2322/4885 |
| US-11633415-B2 | Compounds and methods useful for treating or preventing cancers | CSNK1A1, CSNK2A1, CSNK2A3 | LMNA 1021/4885ALDH1A1 626/4885HPGD 2322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.