Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881758 | 0.81 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL21001992 | 0.78 | IDO1 (0.43) | ALDH1A1 | |
| SCHEMBL21002000 | 0.78 | CA1 (0.35) | KDM4EALDH1A1GAA | |
| SCHEMBL29218326 | 0.73 | IRAK4 (0.35) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL20525079 | 0.73 | KDM4E (0.34) | KDM4EMGLLPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL20524364 | 0.71 | PRKAG1 (0.31) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL21001880 | 0.71 | — | — | |
| SCHEMBL21001854 | 0.70 | MAPK8 (0.30) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL17713790 | 0.70 | PRKAG1 (0.31) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 | |
| SCHEMBL3469250 | 0.70 | MAPK8 (0.30) | PRKAG1PRKAA1PRKAB1PRKAA2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |