Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507028 | 0.77 | MMP1 (0.57) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 | |
| SCHEMBL2392196 | 0.75 | PTGDR2 (0.46) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 | |
| SCHEMBL3905295 | 0.75 | PTGS2 (0.43) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 | |
| SCHEMBL7621182 | 0.75 | GAA (0.44) | KMT2ALMNARAB9AALDH1A1 | |
| SCHEMBL9200863 | 0.72 | GPR52 (0.42) | FFAR1FFAR4KMT2ARAB9AALDH1A1 | |
| SCHEMBL3626720 | 0.72 | CTBP2 (0.46) | KMT2APTGS2ALDH1A1 | |
| SCHEMBL9890721 | 0.72 | MLNR (0.47) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 | |
| SCHEMBL2391383 | 0.72 | SLC6A4 (0.49) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 | |
| SCHEMBL3437801 | 0.70 | KMT2A (0.60) | FFAR1FFAR4PTGDR2KMT2APTGS1 | |
| SCHEMBL1041243 | 0.70 | PDK2 (0.49) | FFAR1FFAR4PTGDR2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516416-A1 | CRTH2 MODULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011079007-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |