Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525821 | 0.94 | MET (0.54) | METKDRFLT3IGF1R | |
| SCHEMBL20525671 | 0.93 | MET (0.48) | METKDRFLT3 | |
| SCHEMBL20525650 | 0.91 | MET (0.49) | METKDRPDE4APDE4BPDE4C | |
| SCHEMBL20525673 | 0.89 | MET (0.49) | METKDRFLT3IGF1RAXL | |
| SCHEMBL20525800 | 0.88 | MET (0.51) | METKDRFLT3AXL | |
| SCHEMBL20525607 | 0.88 | MET (0.58) | METKDRFLT3IGF1RAXL | |
| SCHEMBL371776 | 0.88 | MET (0.66) | METKDRFLT3AXL | |
| SCHEMBL20525606 | 0.88 | MET (0.50) | METKDRFLT3AXL | |
| SCHEMBL20525632 | 0.86 | MET (0.53) | METKDRFLT3AXL | |
| SCHEMBL20525653 | 0.86 | MET (0.48) | METKDRFLT3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |