Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525821 | 0.93 | MET (0.54) | METKDRFLT3 | |
| SCHEMBL20525522 | 0.91 | MET (0.51) | METAXLKDRPOLBEGFR | |
| SCHEMBL20525607 | 0.91 | MET (0.58) | METAXLKDRFLT3 | |
| SCHEMBL20525673 | 0.91 | MET (0.49) | METAXLKDREGFRKIT | |
| SCHEMBL20525823 | 0.89 | POLB (0.47) | METAXLKDRPOLB | |
| SCHEMBL20525717 | 0.88 | MET (0.52) | METKDRFLT3 | |
| SCHEMBL20525810 | 0.88 | MET (0.68) | METAXLKDRKITFLT3 | |
| SCHEMBL20525606 | 0.88 | MET (0.50) | METAXLKDRFLT3 | |
| SCHEMBL20525537 | 0.87 | MET (0.52) | METKDREGFRFLT3 | |
| SCHEMBL20525800 | 0.87 | MET (0.51) | METAXLKDREGFRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |