Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | MST1R | Q04912 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525684 | 0.91 | MET (0.47) | METKDRAXLTDP1EGFR | |
| SCHEMBL20525632 | 0.91 | MET (0.53) | METKDRAXLEGFRFLT3 | |
| SCHEMBL20525535 | 0.89 | MET (0.51) | METKDRAXLFLT3IGF1R | |
| SCHEMBL20525606 | 0.89 | MET (0.50) | METKDRAXLFLT3 | |
| SCHEMBL20525821 | 0.88 | MET (0.54) | METKDRFLT3IGF1R | |
| SCHEMBL20525800 | 0.88 | MET (0.51) | METKDRAXLEGFRFLT3 | |
| SCHEMBL20525607 | 0.88 | MET (0.58) | METKDRAXLFLT3IGF1R | |
| SCHEMBL371696 | 0.88 | MET (0.64) | METKDRAXLEGFRFLT3 | |
| SCHEMBL20525823 | 0.88 | POLB (0.47) | METKDRAXLIGF1R | |
| SCHEMBL20525671 | 0.87 | MET (0.48) | METKDRFLT3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |