Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525675 | 0.92 | POLB (0.58) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL20525714 | 0.90 | MET (0.47) | METKDRPOLB | |
| SCHEMBL20525748 | 0.88 | MET (0.49) | METKDR | |
| SCHEMBL20525667 | 0.87 | MET (0.53) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL20525820 | 0.87 | MET (0.51) | METKDR | |
| SCHEMBL20525821 | 0.87 | MET (0.54) | METKDR | |
| SCHEMBL1484298 | 0.86 | MET (0.69) | METKDRPDGFRA | |
| SCHEMBL20525580 | 0.85 | MET (0.51) | METKDRAXL | |
| SCHEMBL20525731 | 0.84 | MET (0.49) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL20525545 | 0.84 | MET (0.53) | METKDRAXLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |