Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 19/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525726 | 0.95 | POLB (0.44) | POLBMETKDRIGF1RAXL | |
| SCHEMBL20525804 | 0.91 | POLB (0.48) | POLBMETKDRAXL | |
| SCHEMBL20525585 | 0.90 | MET (0.52) | POLBMETKDRIGF1RAXL | |
| SCHEMBL20525632 | 0.89 | MET (0.53) | POLBMETKDRAXL | |
| SCHEMBL20525675 | 0.88 | POLB (0.58) | POLBMETKDRAXL | |
| SCHEMBL20525673 | 0.88 | MET (0.49) | METKDRIGF1RAXL | |
| SCHEMBL371592 | 0.87 | MET (0.60) | METKDRAXL | |
| SCHEMBL20525821 | 0.87 | MET (0.54) | METKDRIGF1R | |
| SCHEMBL20525522 | 0.85 | MET (0.51) | POLBMETKDRAXL | |
| SCHEMBL20525591 | 0.85 | MET (0.51) | POLBMETKDRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |