Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | MET | P08581 | 16/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | STK25 | O00506 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | MUSK | O15146 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | PAK3 | O75914 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525808 | 0.89 | MET (0.48) | FLT3METINSRKDRMAP4K1 | |
| SCHEMBL371582 | 0.87 | FLT3 (0.68) | FLT3METINSRKDRMAP4K1 | |
| SCHEMBL20525825 | 0.87 | MET (0.58) | FLT3METINSRKDRMAP4K1 | |
| SCHEMBL20525826 | 0.82 | MET (0.45) | METKDRIGF1RAXL | |
| SCHEMBL20525675 | 0.81 | POLB (0.58) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL20525748 | 0.81 | MET (0.49) | METKDRIGF1R | |
| SCHEMBL20525633 | 0.80 | MET (0.52) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL20525545 | 0.80 | MET (0.53) | METKDRAXL | |
| SCHEMBL2280583 | 0.79 | MET (0.58) | FLT3METINSRKDRMAP4K1 | |
| SCHEMBL20525760 | 0.79 | MET (0.57) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |