Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693537 | 0.84 | KDR (0.54) | AXLMERTKPDGFRAKDR | |
| SCHEMBL372050 | 0.84 | KDR (0.54) | AXLMERTKPDGFRAKDR | |
| SCHEMBL20525878 | 0.83 | PDGFRA (0.47) | AXLMERTKPDGFRAKDR | |
| SCHEMBL20525528 | 0.83 | AXL (0.46) | AXLMERTKUSP2ALDH1A1PDGFRA | |
| SCHEMBL20525674 | 0.82 | AXL (0.53) | AXLMERTKUSP2MAPTPDGFRA | |
| SCHEMBL20525801 | 0.82 | POLB (0.52) | AXLMERTKTHRBHTTPOLB | |
| SCHEMBL20525750 | 0.80 | KDR (0.47) | AXLMERTKTHRBPOLBUSP2 | |
| SCHEMBL20525663 | 0.80 | MET (0.56) | AXLMERTKPDGFRAKDR | |
| SCHEMBL20525766 | 0.79 | ALDH1A1 (0.49) | AXLMERTKUSP2ALDH1A1PDGFRA | |
| SCHEMBL20525705 | 0.79 | AXL (0.45) | AXLMERTKUSP2ALDH1A1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |