Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230342 | 0.84 | HSD11B1 (0.63) | HSD11B1HSD11B2 | |
| SCHEMBL2052199 | 0.75 | HSD11B1 (0.68) | HSD11B1MEN1KMT2AHSD11B2 | |
| SCHEMBL2053950 | 0.75 | HSD11B1 (0.50) | ALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL232027 | 0.73 | HSD11B1 (0.76) | HSD11B1HSD11B2 | |
| SCHEMBL230990 | 0.72 | HSD11B1 (0.62) | ALDH1A1HSD11B1MEN1KMT2AHSD11B2 | |
| SCHEMBL2823259 | 0.71 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL2823256 | 0.71 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL230248 | 0.69 | HSD11B1 (0.64) | HSD11B1HSD11B2 | |
| SCHEMBL2823260 | 0.67 | HSD11B1 (0.42) | ALDH1A1SMN1; SMN2TSHRHTTNPSR1 | |
| SCHEMBL7425098 | 0.65 | MEN1 (0.52) | ALDH1A1HTTNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |