Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.68 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL234728 | 0.81 | HSD11B1 (1.00) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL2053950 | 0.76 | HSD11B1 (0.50) | HSD11B1MEN1KMT2A | |
| SCHEMBL233150 | 0.76 | HSD11B1 (0.74) | HSD11B1HSD11B2 | |
| SCHEMBL2052823 | 0.75 | ALDH1A1 (0.47) | HSD11B1HSD11B2MEN1KMT2A | |
| SCHEMBL232023 | 0.71 | HSD11B1 (0.67) | HSD11B1HSD11B2 | |
| SCHEMBL28047796 | 0.67 | HSD11B1 (0.37) | HSD11B1EPHX1KDM4EEPHX2KMT2A | |
| SCHEMBL230596 | 0.66 | HSD11B1 (0.74) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL2824586 | 0.65 | HSD11B1 (0.68) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL2824589 | 0.65 | HSD11B1 (0.68) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL13255634 | 0.65 | HSD11B1 (0.46) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |