Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231438 | 0.84 | HSD11B1 (0.61) | HSD11B1GRIN1GRIN2BKCNH2HRH3 | |
| SCHEMBL2052199 | 0.76 | HSD11B1 (0.68) | HSD11B1MEN1KMT2A | |
| SCHEMBL2052823 | 0.75 | ALDH1A1 (0.47) | HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL28597356 | 0.73 | GRIN1 (0.67) | GRIN1GRIN2BKCNH2HRH3POLB | |
| Hydrochloric Acid SCHEMBL4577195 | 0.73 | KCNH2 (0.65) | GRIN1GRIN2BKCNH2HRH3POLB | |
| SCHEMBL8817072 | 0.73 | KCNH2 (0.61) | GRIN1GRIN2BKCNH2HRH3POLB | |
| SCHEMBL2822073 | 0.72 | HSD11B1 (0.44) | HSD11B1GRIN1GRIN2B | |
| SCHEMBL2822075 | 0.72 | HSD11B1 (0.44) | HSD11B1GRIN1GRIN2B | |
| SCHEMBL10735474 | 0.71 | GRIN2B (0.73) | GRIN1GRIN2BKCNH2HRH3POLB | |
| SCHEMBL10733415 | 0.69 | GRIN2B (0.71) | GRIN1GRIN2BKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |