Dl-Dithiothreitol

Dl-Dithiothreitol

SCHEMBL2052829

OCCS.O[C@H](CS)[C@H](O)CS

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.42
TDP1 Q9NUW8 2/20 0.35
NR1I2 O75469 1/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
HTT P42858 1/20 0.35
HSD17B10 Q99714 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Dithiothreitol SCHEMBL27262405 1.00 LMNA (0.42) LMNATDP1NR1I2ALDH1A1CYP1A2
Dithiothreitol SCHEMBL28079600 1.00 LMNA (0.42) LMNATDP1NR1I2ALDH1A1CYP1A2
Dl-Dithiothreitol SCHEMBL78921 0.84
Dl-Dithiothreitol SCHEMBL21114401 0.84 LMNA (0.44) LMNATDP1NR1I2ALDH1A1CYP1A2
Dl-Dithiothreitol SCHEMBL17370231 0.84
Dl-Dithiothreitol SCHEMBL14496668 0.84
Dithiothreitol SCHEMBL538995 0.84
Dl-Dithiothreitol SCHEMBL21114400 0.84 LMNA (0.44) LMNATDP1NR1I2ALDH1A1CYP1A2
Dl-Dithiothreitol SCHEMBL87345 0.84
Dl-Dithiothreitol SCHEMBL10601 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117929704-A Detection box for detecting inflammatory bowel disease through fecal sample 中南大学湘雅医院 2024-04-26 CN claimed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP claimed
WO-2005065074-A2 PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2005-07-21 WO claimed
WO-2005044181-A2 PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2005-05-19 WO claimed
US-20220009956-A1 PREPARATION OF OLIGO CONJUGATES EMERALD THERAPEUTICS INC (US) 2022-01-13 US disclosed
EP-3819376-A1 COMPOSITION AND METHOD FOR IMPROVING EFFICIENCY OF SMALL RNA EXTRACTION Daiyukai Health System (JP) 2021-05-12 EP disclosed
US-20160333045-A1 Preparation of Oligo Conjugates Emerald Therapeutics, Inc. 2016-11-17 US disclosed
US-9289502-B2 Preparation of oligo conjugates Emerald Therapeutics, Inc. (US) 2016-03-22 US disclosed
WO-2014138373-A1 PREPARATION OF OLIGO CONJUGATES Emerald Therapeutics, Inc. (US) 2014-09-12 WO disclosed
US-20140256911-A1 PREPARATION OF OLIGO CONJUGATES Emerald Therapeutics, Inc. 2014-09-11 US disclosed
EP-2334748-A1 PROTEIN/CATIONIC POLYMER COMPOSITIONS HAVING REDUCED VISCOSITY Hercules Incorporated (US) 2011-06-22 EP disclosed
WO-2010028062-A1 PROTEIN/CATIONIC POLYMER COMPOSITIONS HAVING REDUCED VISCOSITY HERCULES INCORPORATED (US) 2010-03-11 WO disclosed
WO-2006084016-A1 ACID ADDITION SALTS OF Ac-PHSCN-NH2 ATTENUON, LLC (US) 2006-08-10 WO disclosed
WO-2005065074-A2 PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2005-07-21 WO disclosed
WO-2005044181-A2 PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2005-05-19 WO disclosed
JP-2004315520-A AUTOIMMUNITY POTENTIATING AGENT, METHOD FOR PRODUCING THE SAME, AND COSMETIC BY USING THE SAME NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL & TECHNOLOGY 2004-11-11 JP disclosed
US-20040058364-A1 Modified nucleotides and methods useful for nucleic acid sequencing INVITROGEN CORPORATION 2004-03-25 US disclosed
WO-1999049082-A2 MODIFIED NUCLEOTIDES AND METHODS USEFUL FOR NUCLEIC ACID SEQUENCING INVITROGEN CORPORATION (US) 1999-09-30 WO disclosed
US-5897857-A SULFHYDRYL COMPOUND SELECTED FROM CYSTEINE, HOMOCYCTEINE, GLUTATHIONE, THIOGLYCEROL, THIOMALIC ACID, 2-MERCAPTOETHANOL, MERCAPTOPROPIONIC ACIDS, DITHIOTHREITOL, THIOSALICYLIC ACID, N-ACETYL-L-CYSTEIN AND SALTS; FACIAL HAIR REMOVER THE PROCTER & GAMBLE COMPANY (US) 1999-04-27 US disclosed
US-RE35500-E Direct radiolabeling of antibodies and other proteins with technetium or rhenium ABERLYN CAPITAL MANAGEMENT LIMITED PARTNERSHIP (US) 1997-05-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160333045-A1 Preparation of Oligo Conjugates OSTC, PCBP1, PAICS LMNA 3846/4885TDP1 2904/4885NR1I2 3056/4885
US-20220009956-A1 PREPARATION OF OLIGO CONJUGATES OSTC, PCBP1, PAICS LMNA 3846/4885TDP1 2904/4885NR1I2 3056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.