SCHEMBL2052877

SCHEMBL2052877

c1ccc(Nc2ccc3cc[nH]c3c2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.55
HSD17B10 Q99714 4/20 0.55
HPGD P15428 2/20 0.55
CYP3A4 P08684 1/20 0.55
SYK P43405 1/20 0.49
MEN1 O00255 1/20 0.48
AR P10275 1/20 0.48
MAPT P10636 1/20 0.48
KMT2A Q03164 1/20 0.48
ALOX15 P16050 1/20 0.48
TSHR P16473 1/20 0.48
ALOX12 P18054 1/20 0.48
PTGS1 P23219 1/20 0.48
SLC6A2 P23975 1/20 0.48
MAPK1 P28482 1/20 0.48
PTGS2 P35354 1/20 0.48
HTR2B P41595 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MAOA P21397 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12129007 0.90 SYK (0.55) SYKMEN1KMT2AMAPK1MAOA
SCHEMBL12127169 0.85 MAOB (0.64) ALDH1A1HSD17B10HPGDCYP3A4MEN1
SCHEMBL12129516 0.83 SYK (0.50) SYKMAPTALOX15MAOAMAOB
SCHEMBL5148079 0.83 AHR (0.58) ALDH1A1SYKMAPTAHREGFR
Diphenylamine SCHEMBL10617435 0.82 TRPA1 (0.71) ALDH1A1HSD17B10HPGDCYP3A4MEN1
SCHEMBL8788688 0.82 SYK (0.50) SYKPRKCQAHREGFRCMA1
SCHEMBL21257479 0.79 KIF11 (0.49) SYKTSHRL3MBTL1MAOAEGFR
SCHEMBL29581605 0.78 MAPK14 (0.50) ALDH1A1HSD17B10HPGDSYKMEN1
SCHEMBL27375907 0.78 NPC1 (0.61) MEN1MAPTKMT2ATSHRMAOA
SCHEMBL20179811 0.77 NPC1 (0.74) MAPTPTGS2MAOAMAOBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2558446-B1 NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS AC IMMUNE SA (CH) 2019-06-12 EP disclosed
EP-2509954-A1 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2012-10-17 EP disclosed
WO-2011072241-A1 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-06-16 WO disclosed
EP-1974212-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH Vertex Pharmaceuticals Incorporated (US) 2008-10-01 EP disclosed
WO-2007075946-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-07-05 WO disclosed