Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.58 |
| ▸ | CMA1 | P23946 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129007 | 0.84 | SYK (0.55) | AHRCMA1ESR1SYKEGFR | |
| SCHEMBL2052877 | 0.83 | ALDH1A1 (0.55) | AHRCMA1ESR1SYKMAPT | |
| SCHEMBL12129516 | 0.78 | SYK (0.50) | AHRCMA1ESR1SYKF7 | |
| SCHEMBL21257479 | 0.77 | KIF11 (0.49) | ESR1SYKHTTGRM4EGFR | |
| SCHEMBL1686631 | 0.76 | FADS1 (0.59) | FADS1MAPTALDH1A1HTTGAA | |
| SCHEMBL30302564 | 0.76 | AHR (0.56) | AHRCMA1ESR1PYGLSYK | |
| SCHEMBL22803637 | 0.76 | AHR (0.56) | AHRCMA1ESR1PYGLSYK | |
| SCHEMBL415078 | 0.75 | HTR3E (0.51) | TTBK1TTBK2GRM5FADS1MAPT | |
| SCHEMBL12521749 | 0.75 | BTK (0.43) | ESR1SYKMAPTEGFR | |
| SCHEMBL5664020 | 0.75 | AHR (0.63) | AHRCMA1F7LTA4HF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1974212-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | Vertex Pharmaceuticals Incorporated (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007075946-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |